Dulaglutide

Product Name：   Dulaglutide biosimilar

CAS No.:    923950-08-7                            

Formula:     C₂₆₄₆H₄₀₄₄N₇₀₄O₈₃₆S₁₈                        

Molecular Weight：  63 kDa             

Type:    Fusion protein                     

Target：   GLP-1
Antibody Form:   Purified immunoglobulin
Physical Form:    Solution
Storage:  -70±15℃ for long-term storage, 2-8℃ for short-term storage, away from light.

Description

Dulaglutide biosimilar is a fusion protein that consists of 2 identical, disulfide-linked chains, each containing an N-terminal GLP-1 analog sequence covalently linked to the Fc portion of a modified human immunoglobulin G4 (IgG4) heavy chain by a small peptide linker and is produced using mammalian cell culture. The GLP-1 analog portion of dulaglutide is 90% homologous to native human GLP-1 (7-37). Structural modifications were introduced in the GLP-1 part of the molecule responsible for interaction with the enzyme dipeptidyl-peptidase-IV (DPP-4). Additional modifications were made in an area with a potential T-cell epitope and in the areas of the IgG4 Fc part of the molecule responsible for binding the high-affinity Fc receptors and half-antibody formation. The overall molecular weight of dulaglutide is approximately 63 kilodaltons.